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In addition, the observed side-chain flexibility of V12 and F112 indicated that these residues are mainly involved in the overall shaping of the active site and help to position the flavonoid substrate in accordance with the presented structural evidence

Moderate consumption of filtered coffee (1-3 cups per day) may be linked to a reduced chance of developing hyperhomocysteinemia, as reported by a cross-sectional study population of 557 adults with an average age of 45 years that included 58% non-smokers, 78% with low activity levels and 74% non-obese, from south-eastern Brazil (Miranda et al, 2017)